Identification and functional characterisation of diagnostic epitopes and molecular mimics in mycobacterial infection

Description of the research topic:

T cell epitope mapping using synthetic peptides has emerged as one of the most powerful tools for the development of diagnostics. Peptide antigens are efficient in provoking in vitro T cell response. The use of peptides represents an advantage as they do not require uptake and processing, and can be presented directly by the HLA molecules. The antigenicity and presentation of the synthetic antigens as peptides can be further enhanced by conjugation to selected peptide carriers. The major reason for the need of the new generation of synthetic antigens should be considered that the different populations may respond to different peptides. In our project the following goals will be achieved: (i) identification of the population specific functional T cell epitopes of mycobacteria related proteins (ii) characterisation of peptide-conjugates to optimise the immune recognition of T cell epitope peptides.

Thesis supervisor: Szilvia Bősze

Required language skills: English,
Recommended language skills: Hungarian
Further requirements: biology MSc, chemistry MSc, Miscrosoft Office, Origin, Prism, basic cell culture experience

How to Apply?

If you are interested apply here: [PhD] Hevesy György PhD School of Chemistry – Eötvös Loránd University (elte.hu)

For more information visite the following website: Doctoral School of Chemistry (elte.hu)

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